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Adverse drug reaction reports between 1978 and 1987 in Denmark; no tetracycline is mentioned as a cause).
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The mutations in the interdomain loop region of the tetA (A) tetracycline resistance gene increase the efflux of minocycline and the glycylcyclines.
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These molecules are of no interest as therapeutic candidates because they cause adverse side effects in humans (), which are probably related to their ability to interact nonspecifically with eukaryotic as well as prokaryotic cell membranes ().
It is best combined with Kanamycin for effective treatment of Columnaris pathogens, in fact the COMBINATION of Nitrofurazone and Kanamycin is often the only effective treatment for Columnaris.
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In the preparation of a metal salt of tetracycline, it is also important that a strong base be used.
Secondary changes include villous atrophy in the small intestine and reduced disaccharidase activity of the brush border.
Association of tetracyclines with the ribosome is reversible, providing an explanation of the bacteriostatic effects of these antibiotics ().
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The tet(X) gene encodes an enzyme which modifies and inactivates the tetracycline molecule ().
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Several endogenous promoters had been identified that responded to stimuli, such as hormones or metal ions; however, these systems were confounded by secondary effects.
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Tetracycline Plus Teeth Equal Gray Smile Date: July 31, 2006 Source: Academy of General Dentistry Summary: Many adults over age 35 cover their mouth to avoid smiling in public in order to hide their teeth darkened by tetracycline stains.
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