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Routine therapeutic drug monitoring reports only total vancomycin concentrations, although protein binding varies and it is generally accepted that only free drug is active.

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McKinnell JA, Patel M, Shirley RM, Kunz DF, Moser SA, Baddley JW: Observational study of the epidemiology and outcomes of vancomycin-resistant Enterococcus bacteraemia treated with newer antimicrobial agents.

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