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The Therapeutic Goods Administration (TGA) has sent a reminder to all healthcare professionals to be alert for the signs and symptoms of drug-induced acute akathisia in patients prescribed typical and atypical antipsychotics.
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Fourth, cloning and pharmacological characterization of multiple serotonin receptor subtypes, including the 5-HT 1A (), 5-HT 2A (), and 5-HT 2C () serotonin receptor, provide an opportunity to examine the relationship between antipsychotic binding affinities to these serotonin receptor subtypes and clinically effective antipsychotic drug dosages, an analysis not possible in 1976.
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This hypothesis was supported by PET and SPECT findings, which showed that a reduced striatal density of unoccupied dopamine D 2-receptors is correlated with extrapyramidal side-effects in neuroleptic-treated individuals with schizophrenia and with craving and dysphoria in drug-dependent patients.
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International consensus guidelines recommend that surgical patients who develop PONV should be treated with an antiemetic with a different mechanism of action from any antiemetic given before surgery for the prevention of PONV.
The studies addressing models of care indicate that the type of antipsychotic, the mode of psychotherapy, treatment of comorbid disorders and consideration of factors influencing adherence all impact treatment outcome.
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Colonna L, Saleem P, Dondey-Nouvel L, Rein W: Long-term safety and efficacy of amisulpride in subchronic or chronic schizophrenia.
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Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1) Archives of general psychiatry.
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Therefore, all efficacy analyses are presented on the “maintenance” population (patients exposed to treatment for more than two months, with at least one evaluation after that period).
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