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During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys.

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Therapeutic implications of peptide interactions with G-protein-coupled receptors in diabetic vasculopathy.

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The diuretic, natriuretic, and antihypertensive effects of olmesartan and the antihypertensive effects of telmisartan may be reduced.

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Because MI impairs the circulatory function of the heart, oxygen extraction by the heart and by other tissues may be diminished.

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Adults and children aged 10 years or older with type 1 diabetes should have an initial dilated and comprehensive eye examination by an ophthalmologist or optometrist within 5 years after the onset of diabetes.

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Medications for the relief of specific symptoms related to painful DPN and autonomic neuropathy are recommended, as they improve the quality of life of the patient.

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In particular, we aimed to characterize the mechanisms by which microalbuminuria develops in early type 2 diabetic nephropathy by focusing on the heterogeneity of glomerular podocyte abnormalities in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which exhibit pathological features of renal injury similar to those found in human type 2 diabetic patients with hypertension, obesity, and hyperinsulinemia.

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In patients with known CVD, consider ACE inhibitor therapy (C) and use aspirin and statin therapy (A) (if not contraindicated) to reduce the risk of cardiovascular events.

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Angioedema: Angioedema has been reported rarely with some angiotensin II receptor antagonists (ARBs) and may occur at any time during treatment (especially following first dose).

The cost-effectiveness of interventions in diabetes: A review of published economic evaluations in the UK setting, with an eye on the future.

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