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The main metabolite is desethylChloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylChloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts.

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Survey of resistance to chloroquine of falciparum and vivax malaria in Palawan, the Philippines.

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Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-Related Eye Disease Study (CAREDS).

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The influence of genetic innate resistance and acquired immunity on drug treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania.

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Extended haplotype heterozygosity (EHH) around surrounding Plasmodium falciparum chloroquine resistance transporter ( pfcrt) in chloroquine-resistant parasites and chloroquine-susceptible parasites from 1992 through 1995 and in 2005.

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The role of grandmothers and mothers-in-law as key decision makers regarding cases of degedege was an important finding of the study, suggesting that these individuals be specifically targeted with information and teaching regarding severe malaria (Comoro et al.

Hatabu T, Iwagami M, Kawazu S, Taguchi N, Escueta AD, Villacorte EA, Rivera PT, Kano S: Association of molecular markers in Plasmodium falciparum crt and mdr1 with in vitro chloroquine resistance: A Philippine study.

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Continued incubation resulted in a gradual fading of cell surface staining and an increased intracellular accumulation of DPCs in vesicular compartments.

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Yang HL, Liu DQ, Huang KG, Yang PF, Yang YM, Liao MZ, Zhang CY, Liu RJ: In vitro assay of the sensitivity of Plasmodium falciparum to the derivatives of artemisimin, pyronaridine and chloroquine in Yunnan.

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Regulated oligomerisation and molecular interactions of the early gametocyte protein Pfg27 in Plasmodium falciparum sexual differentiation.

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It is useful in gastropathy, diarrhoea, dysentery, intermittent fevers, ophthalmopathy, scabies, ulcers and wounds.

The results suggest the safety of sulphadoxine-pyrimethamine and chloroquine in preservation of semen ex vivo while the negative impact of mefloquine could reside within the testis or epididymis.

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The result -- widespread, chloroquine-sensitive K76T PfCRT in a population -- is medically and epidemiologically interesting, but would have nothing to do with how resistance originally arose.

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